Green tea extract
Green tea extract as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury
Benefits of Green Tea Extract in DILI:
- Antioxidant Properties: Green tea extract is rich in polyphenols, particularly catechins, which have strong antioxidant properties. These antioxidants help to neutralize free radicals and reduce oxidative stress in the liver, which can be beneficial in protecting against DILI.
- Anti-inflammatory Effects: Green tea extract has been shown to have anti-inflammatory effects, which can help reduce inflammation in the liver caused by drug-induced injury. This can help to prevent further damage to liver cells.
- Detoxification Support: Some studies suggest that green tea extract may support the liver's natural detoxification processes, helping to eliminate toxins and drugs that could potentially cause liver damage.
Research on Green Tea Extract and DILI:
Several studies have investigated the potential benefits of green tea extract in protecting against drug-induced liver injury. While more research is needed to fully understand the mechanisms involved, preliminary findings suggest that green tea extract may offer some protection against DILI through its antioxidant and anti-inflammatory properties.
Conclusion:
Green tea extract shows promise as a natural supplement that may help protect the liver from drug-induced injury. However, it is important to consult with a healthcare provider before using green tea extract or any other supplement, especially if you have a history of liver problems or are taking medications that could potentially interact with green tea extract.
Supplements for DILI
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
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Green tea extract
Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.
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Greater celandine
Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.
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Chaparral
Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.
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Germander
Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.
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Mistletoe
Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.
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Skullcap
Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.
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Valerian
Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.
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Kava kava
Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.
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St. John's wort
Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.
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Ginseng
Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.
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Aloe vera
Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.
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Ashwagandha
Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.
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Andrographis
Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.
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Noni juice
Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.
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Peppermint oil
Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.
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Kratom
Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.
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Ephedra
Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.
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